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Chemical Structure : RX-375
Catalog No.: PC-20473Not For Human Use, Lab Use Only.
RX-375 (RX375) is an indirect small-molecule activator of AMPK by directly binds to Prohibitins (PHB1 and PHB2), induces dissociation of AMPK-PHBs complex.
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RX-375 (RX375) is an indirect small-molecule activator of AMPK by directly binds to Prohibitins (PHB1 and PHB2), induces dissociation of AMPK-PHBs complex.
RX-375 does not activate recombinant AMPK proteins composed of α1β1γ1 or α2β1γ1 subunits in vitro at 100 uM.
RX-375 inhibits fatty acid synthesis in HepG2 cells in a PPARα-independent manner, 10,000 times more potent than metformin.
RX-375 exhibits stimulatory and inhibitory effects on AMPKα phosphorylation and fatty acid synthesis, respectively, in primary human hepatocytes.
RX-375 attenuates the interaction between AMPK and PHBs, PHBs are negative regulators of AMPK.
RX-375 (30 mg/kg, oral) increasees AMPKα phosphorylation level, reduces triglyceride content and inhibits fatty acid synthesis in the liver of obese mice.
| M.Wt | 407.45 | |
| Formula | C23H22FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kanagaki S, et al. iScience. 2023 Feb 28;26(4):106293.
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