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ARUK2010489

Chemical Structure : ARUK2010489

CAS No.:

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ARUK2010489 (ARUK-2010489)

Catalog No.: PC-25727Not For Human Use, Lab Use Only.

ARUK2010489 is a potent, selective and highly brain penetrant NUAK1 inhibitor with pIC50 of 8.7, displays no CDK2 activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ARUK2010489 is a potent, selective and highly brain penetrant NUAK1 inhibitor with pIC50 of 8.7, displays no CDK2 activity.

Physicochemical Properties

M.Wt 406.53
Formula C23H30N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(cyclopropylmethoxy)-N-(4-(4-isopropylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

References

1. Aldred GG, et al. ACS Med Chem Lett. 2025 Sep 10;16(11):2264-2272.

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