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Chemical Structure : KI-301670
Catalog No.: PC-47031Not For Human Use, Lab Use Only.
KI-301670 is a novel potent, specific NUAK1 inhibitor, disturbs NUAK1 signaling by targeting its ATP binding site, effectively inhibits the PI3K/AKT pathway in pancreatic cancer cells.
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KI-301670 is a novel potent, specific NUAK1 inhibitor, disturbs NUAK1 signaling by targeting its ATP binding site, effectively inhibits the PI3K/AKT pathway in pancreatic cancer cells.
KI-301670 effectively inhibited pancreatic cancer growth and proliferation, and induced cell cycle arrest, markedly G0/G1 arrest, by increasing the expression of p27 and decreasing expression of p-Rb and E2F1.
KI-301670 effectively inhibited the growth of pancreatic cancer cells in a dose-dependent manner (IC50, 1.7 uM, MIA PaCa-2 and 2.6 uM for AsPC-1 cells).
KI-301670 significantly increased the expression levels of cleaved PARP and decreased the expression of Mcl-1, survivin, and XIAP in pancreatic cancer cells.
KI-301670 (30 mg/kg) inhibited tumor growth in mouse pancreatic cancer xenograft model.
| M.Wt | 451.494 | |
| Formula | C22H28F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Seo MS, et al. Biomed Pharmacother. 2022 Aug;152:113241.
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