| Cat. No. |
Product Name |
Information |
| PC-42982 |
HTH-01-015
NUAK1 inhibitor
|
HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2. |
| PC-62774 |
PF-06685249
AMPK activator
|
PF-06685249 (PF06685249, PF-249) is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 12 nM for α1β1γ1-AMPK. |
| PC-62773 |
PF-06679142
AMPK activator
|
PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK. |
| PC-62013 |
MK-3903
AMPK activator
|
MK-3903 is a potent and selective, direct and oral AMPK activator with EC50 of 9 nM. |
| PC-61181 |
MT47-100
AMPK inhibitor
|
MT47-100 is a novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively. |
| PC-60632 |
PF-06409577
AMPK activator
|
PF-06409577(PF06409577, PF 6409577) is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively. |
| PC-60202 |
AMPK activator 13
AMPK activator
|
AMPK activator 13 is a potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM). |
| PC-60179 |
EX-229
AMPK activator
|
EX-229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM. |
| PC-60138 |
PF-739
AMPK activator
|
PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM. |
| PC-60137 |
MK-8722
AMPK activator
|
MK-8722 is a potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms. |
| PC-45830 |
A-769662
AMPK activator
|
A-769662 is a small molecule AMPK activator that directly stimulates partially purified rat liver AMPK (EC50=0.8 uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50=3.2 uM). |
| PC-45055 |
ZLN-024 hydrochloride
AMPK activator
|
ZLN-024 hydrochloride is a potent, allosteric AMPK activator that has no effect on mitochondrial function or the ADP/ATP ratio, directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively. |
