| Cat. No. |
Product Name |
Information |
| PC-60179 |
EX-229
AMPK activator
|
EX-229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM. |
| PC-60138 |
PF-739
AMPK activator
|
PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM. |
| PC-60137 |
MK-8722
AMPK activator
|
MK-8722 is a potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms. |
| PC-45830 |
A-769662
AMPK activator
|
A-769662 is a small molecule AMPK activator that directly stimulates partially purified rat liver AMPK (EC50=0.8 uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50=3.2 uM). |
| PC-45055 |
ZLN-024 hydrochloride
AMPK activator
|
ZLN-024 hydrochloride is a potent, allosteric AMPK activator that has no effect on mitochondrial function or the ADP/ATP ratio, directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively. |
| PC-45054 |
ZLN-024
AMPK activator
|
ZLN-024 is a potent, allosteric AMPK activator that has no effect on mitochondrial function or the ADP/ATP ratio, directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively. |
| PC-22623 |
KHKI-01215
NUAK2 inhibitor
|
KHKI-01215 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 52 nM. |
| PC-22622 |
KHKI-01128
NUAK2 inhibitor
|
KHKI-01128 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 24 nM. |
| PC-22496 |
pan AMPK activator compound 1
AMPK activator
|
pan-AMPK activator compound 1 is a potent, selective small molecule pan AMPK activator with EC50 of 25.9/259 nM and 72.7/170 nM for human and rat α1β2γ1/α2β1γ1, respectively. |
| PC-21279 |
WZ4003
NUAK inhibitor
|
WZ4003 is a potent, highly specific protein kinase inhibitor of NUAK kinase with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. |
| PC-20481 |
Metformin
AMPK activator
|
Metformin (1,1-Dimethylbiguanide) is a traditional anti-diabetic drug, functions by inhibiting complex I in the mitochondrial respiratory chain, activates AMPK and enhances insulin sensitivity. |
| PC-20056 |
BI-9774
AMPK activator
|
BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay. |
