| Cat. No. |
Product Name |
Information |
| PC-43519 |
AICAR
AMPK activator
|
AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes. |
| PC-43240 |
Ampkinone
AMPK activator
|
Ampkinone is a small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM). |
| PC-42982 |
HTH-01-015
NUAK1 inhibitor
|
HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2. |
| PC-62774 |
PF-06685249
AMPK activator
|
PF-06685249 (PF06685249, PF-249) is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 12 nM for α1β1γ1-AMPK. |
| PC-62773 |
PF-06679142
AMPK activator
|
PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK. |
| PC-62464 |
O304
AMPK activator, PCSK9 modulator
|
O304 (O-304, ATX-304) is a small molecule pan-AMPK activated protein kinase (AMPK) activator and PCSK9 modulator, reduces extracellular and secreted PCSK9 levels in human liver cells and reduces PCSK9 plasma levels and total cholesterol levels in obese rats. |
| PC-62013 |
MK-3903
AMPK activator
|
MK-3903 is a potent and selective, direct and oral AMPK activator with EC50 of 9 nM. |
| PC-61181 |
MT47-100
AMPK inhibitor
|
MT47-100 is a novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively. |
| PC-60632 |
PF-06409577
AMPK activator
|
PF-06409577(PF06409577, PF 6409577) is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively. |
| PC-60202 |
AMPK activator 13
AMPK activator
|
AMPK activator 13 is a potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM). |
| PC-60179 |
EX-229
AMPK activator
|
EX-229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM. |
| PC-60138 |
PF-739
AMPK activator
|
PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM. |
