Catalog No.: PC-62774Not For Human Use, Lab Use Only.
PF-06685249 (PF06685249, PF-249) is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 12 nM for α1β1γ1-AMPK.
PF-06685249 (PF06685249, PF-249) is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 12 nM for α1β1γ1-AMPK.
PF-06685249 (PF06685249, PF-249) shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3).
PF-06685249 (PF06685249, PF-249) demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.
