Cat. No. |
Product Name |
Information |
PC-20473 |
RX-375
AMPK activator
|
RX-375 (RX375) is an indirect small-molecule activator of AMPK by directly binds to Prohibitins (PHB1 and PHB2), induces dissociation of AMPK-PHBs complex. |
PC-47031 |
KI-301670
NUAK1 inhibitor
|
KI-301670 is a novel potent, specific NUAK1 inhibitor, disturbs NUAK1 signaling by targeting its ATP binding site, effectively inhibits the PI3K/AKT pathway in pancreatic cancer cells. |
PC-47024 |
PXL770
AMPK activator
|
PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation. |
PC-47019 |
RSVA405
AMPK activator
|
RSVA405 is a small-molecule activator of AMPK, facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR and promotes autophagy to increase Aβ degradation by the lysosomal system with EC50 of 1 uM. |
PC-38664 |
MSG011
pan AMPK activator
|
MSG011 is a potent, pan AMPK isoform activator with EC50 of 140.4 nM, 248.9 nM, 553.4 nM, and 472.9 nM for α1β1γ1, α1β2γ1, α2β1γ1, and α2β2γ1, respectively. |
PC-73284 |
HTH-02-006
NUAK2 inhibitor
|
HTH-02-006 is a potent, selective reversible inhibitor of NUAK1/2 with binding IC50 of 8/126 nM, respectively. |
PC-36018 |
COH-SR4
AMPK activator
|
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling. |
PC-35642 |
BL-AD008
AMPK activator
|
BL-AD008 (BL-AD 008) is a novel small molecule, dual-target activator targeting AMPK/ZIPK. |
PC-35496 |
AMPK activator 991
AMPK activator
|
AMPK activator 991 is an allosteric AMPK activator, activates non-phosphorylated Thr172 AMPK in vitro, binds to α1β1γ1 and α2β1γ1 with Kd of 0.13 and 0.17 uM, respectively. |
PC-35495 |
AMPK activator SC4
AMPK activator
|
AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle. |
PC-35414 |
GSK621
AMPK activator
|
GSK621 (GSK-621) is a potent, specific AMPK agonist (activator), induces cytotoxicity in AML (IC50=13-30 uM) but not in normal hematopoietic cells. |
PC-35331 |
BAY-3827
AMPK inhibitor
|
BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK with IC50 of 0.4 nM (10 µM ATP) and 15 nM (2 mM ATP), respectively. |