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Chemical Structure : RSVA405
CAS No.: 140405-36-3
Catalog No.: PC-47019Not For Human Use, Lab Use Only.
RSVA405 is a small-molecule activator of AMPK, facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR and promotes autophagy to increase Aβ degradation by the lysosomal system with EC50 of 1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RSVA405 is a small-molecule activator of AMPK, facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR and promotes autophagy to increase Aβ degradation by the lysosomal system with EC50 of 1 uM.
RSVA405 inhibited 3T3-L1 adipocyte differentiation by interfering with mitotic clonal expansion during preadipocyte proliferation with IC50 of 0.5 uM.
RSVA405 prevented the adipogenesis-dependent transcriptional changes of multiple gene products involved in the adipogenic process, including PPARγ, CCAAT/enhancer-binding protein α (C/EBPα), fatty acid synthase, fatty acid binding protein 4 (aP2), RANTES or resistin.
RSVA405 (20 and 100 mg/kg/d, oral) significantly reduced the body weight gain of mice fed a high-fat diet.
RSVA405 potently inhibited both constitutive and stimulated STAT3 activity in HEK293 cells and LPS-stimulated RAW 264.7 macrophages, respectively.
| M.Wt | 312.37 | |
| Formula | C17H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid |
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1. Vingtdeux V, et al. Mol Med. 2011 Sep-Oct;17(9-10):1022-30.
2. Capiralla H, et al. FEBS J. 2012 Oct;279(20):3791-9.
3. Vingtdeux V, et al. FASEB J. 2011 Jan;25(1):219-31.
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