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Chemical Structure : BI-9774
Catalog No.: PC-20056Not For Human Use, Lab Use Only.
BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay.
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BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay.
BI-9774 activates all human AMPK isoforms tested as well as rat AMPK (α1β1γ1) with EC50 values below 100 nM.
BI-9774 could acutely improve glucose tolerance, increase muscle glucose uptake and lactate and glycogen in rodents.
BI-9774 also showed reduction in inotropism and heart rate in acute cardiovascular studies in anesthetized rats.
| M.Wt | 541.02 | |
| Formula | C26H25ClN4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent WO2015007669 A1.
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