KHKI-01128 | NUAK2 inhibitor | Probechem Biochemicals

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Chemical Structure : KHKI-01128

KHKI-01128 (KHKI 01128)

Catalog No.: PC-22622Not For Human Use, Lab Use Only.

KHKI-01128 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 24 nM.

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Biological Activity

KHKI-01128 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 24 nM.
KHKI-01128 suppresses cell proliferation IC50 of 1.26 μM, and induces apoptosis of SW480 cells.
KHKI-01128 effectively suppresses the expression of YES1-associated transcriptional regulator (YAP) target genes.

Physicochemical Properties

M.Wt	582.63
Formula	C29H33F3N8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenoxy)-2-((4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carbonitrile

References

1. Seung Hyeong Lee, et al. Anticancer Res. 2024 Jul;44(7):2909-2919.

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KHKI-01128 (KHKI 01128)

Biological Activity

Physicochemical Properties

References

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