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Chemical Structure : PF-06679142
Catalog No.: PC-62773Not For Human Use, Lab Use Only.
PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
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PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
PF-06679142 shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3).
PF-06679142 demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.
| M.Wt | 357.357 | |
| Formula | C20H17F2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Edmonds DJ, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01641.
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