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Chemical Structure : AICAR
CAS No.: 2627-69-2
Catalog No.: PC-43519Not For Human Use, Lab Use Only.
AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $78 | In stock | |
| 200 mg | $128 | In stock | |
| 500 mg | $188 | In stock | |
| 1 g | Get quote |
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AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.
AICAR inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes at 0.5 mM, inhibits insulin-stimulated glucose and reduces GLUT4 translocation in 3T3-L1 adipocytes.
AICAR down-regulates the insulin receptor expression in HepG2 cells.
| M.Wt | 258.23 | |
| Formula | C9H14N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
1H-Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl- |
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1. Sullivan JE, et al. FEBS Lett. 1994 Oct 10;353(1):33-6.
2. Young ME, et al. FEBS Lett. 1996 Mar 11;382(1-2):43-7.
3. Samari HR, et al. J Biol Chem. 1998 Sep 11;273(37):23758-63.
4. Ayasolla KR, et al. J Neuroinflammation. 2005 Sep 20;2:21.
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