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Chemical Structure : CAD-031
Catalog No.: PC-61781Not For Human Use, Lab Use Only.
CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs).
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CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs).
CAD-031 also stimulates the division of NPCs in the subventricular zone of old APPswe/PS1ΔE9 mice.
CAD-031 rescues primary cortical neurons from oxytosis, and effectively reduce oxidative stress with EC50 of 20 nM.
CAD-031 also prevents loss of energy metabolism that leads to neuron cell death in an in vitro ischemia model with EC50 of 47 nM.
CAD-031 target fatty acid metabolism and inflammation, exhibits therapeutic efficacy on cognitive and physiological parameters in mouse model of AD .
| M.Wt | 404.312 | |
| Formula | C18H14F6N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daugherty D, et al. Alzheimers Res Ther. 2017 Jul 14;9(1):50.
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