CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs).
CAD-031 also stimulates the division of NPCs in the subventricular zone of old APPswe/PS1ΔE9 mice.
CAD-031 rescues primary cortical neurons from oxytosis, and effectively reduce oxidative stress with EC50 of 20 nM.
CAD-031 also prevents loss of energy metabolism that leads to neuron cell death in an in vitro ischemia model with EC50 of 47 nM.
CAD-031 target fatty acid metabolism and inflammation, exhibits therapeutic efficacy on cognitive and physiological parameters in mouse model of AD .
