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Chemical Structure : Dorsomorphin dihydrochloride
CAS No.: 1219168-18-9
Catalog No.: PC-43521Not For Human Use, Lab Use Only.
Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $368 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Dorsomorphin (BML-275, Compound C) dihydrochloride is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.
Dorsomorphin inhibits AMPK activation induced by AICAR and Metformin, also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).
Dorsomorphin promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro, induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
| M.Wt | 472.41 | |
| Formula | C24H27Cl2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 48 mg/mL; DMSO: 5.2 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-, hydrochloride (1:2) |
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1. Yu PB, et al. Nat Chem Biol. 2008 Jan;4(1):33-41.
2. Vucicevic L, et al. Autophagy. 2011 Jan;7(1):40-50.
3. Diekmann U, et al. Stem Cells Dev. 2015 Jan 15;24(2):190-204.
4. Zhou G, et al. J Clin Invest. 2001 Oct;108(8):1167-74.
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