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Ampkinone

Chemical Structure : Ampkinone

CAS No.: 1233082-79-5

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Ampkinone

Catalog No.: PC-43240Not For Human Use, Lab Use Only.

Ampkinone is a small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Ampkinone is a small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM).
    Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake in muscle cells.
    Ampkinone significantly reduces total body weight and overall fat mass in DIO mice, effectively improves metabolic abnormalities in the DIO mice model.

    Physicochemical Properties

    M.Wt 505.5174
    Formula C31H23NO6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione, 2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-

    References

    1. Oh S, et al. J Med Chem. 2010 Oct 28;53(20):7405-13.

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