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Ampkinone

Chemical Structure : Ampkinone

CAS No.: 1233082-79-5

Ampkinone

Catalog No.: PC-43240Not For Human Use, Lab Use Only.

Ampkinone is a small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM).

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Biological Activity

Ampkinone is a small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM).
Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake in muscle cells.
Ampkinone significantly reduces total body weight and overall fat mass in DIO mice, effectively improves metabolic abnormalities in the DIO mice model.

Physicochemical Properties

M.Wt 505.5174
Formula C31H23NO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

[1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione, 2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-

References

1. Oh S, et al. J Med Chem. 2010 Oct 28;53(20):7405-13.

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