Hernandezine | AMPK activator | Probechem Biochemicals

Chemical Structure : Hernandezine

CAS No.: 6681-13-6

Hernandezine (Hernandesine)

Catalog No.: PC-27916Not For Human Use, Lab Use Only.

Hernandezine is an alkaloid isolated from roots of Thalictrum podocarpum., is an AMPK activator and induces autophagy and cell death, activates AMPK-mTOR signalling pathways.

Packing	Price	Stock
5 mg	$218	In stock
10 mg	$358	In stock
25 mg	$558	In stock
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Biological Activity

Hernandezine is an alkaloid isolated from roots of Thalictrum podocarpum., is an AMPK activator and induces autophagy and cell death, activates AMPK-mTOR signalling pathways.
Hernandezine inhibits calcium-depletion stimulated calcium entry in human and bovine endothelial cells
Hernandezine is also a potent inhibitor of protein kinase C signaling.
Hernandezine blocks the influx of calcium via non selective cation channels in HL-60 cells.
Hernandezine induces autophagic GFP-LC3 puncta in various types of cancer cells.
Hernandezine induces autophagic cell death in apoptosis-resistant cancer cells.

Physicochemical Properties

M.Wt	652.79
Formula	C39H44N2O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(11S,31S)-16,35,36,37,54-Pentamethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane

References

1. Law BY, et al. Oncotarget. 2016 Feb 16;7(7):8090-104.

2. Low AM, et al. Life Sci. 1996;58(25):2327-35.

3. Ho LJ, et al. Eur J Pharmacol. 1999 Feb 19;367(2-3):389-98.

Hernandezine (Hernandesine)

Biological Activity

Physicochemical Properties

References

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