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Chemical Structure : URMC-099
CAS No.: 1229582-33-5
Catalog No.: PC-43118Not For Human Use, Lab Use Only.
URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | $588 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM.
URMC-099 shows >90% inhibition against 111 kinases in a panel of 442 kinases at 1 uM.
URMC-099 likely functions in HIV-1 associated neurocognitive disorders (HAND) preclinical models by inhibiting multiple kinase pathways, including MLK3 and LRRK2 (IC50=11 nM).
URMC-099 inhibits LPS-induced TNFα release in microglial cells, HIV-1 Tat-induced release of cytokines in human monocytes and up-regulation of phospho-JNK in Tat-injected brains of mice.
| M.Wt | 421.5368 | |
| Formula | C27H27N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrolo[2,3-b]pyridine, 3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]- |
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1. Marker DF, et al. J Neurosci. 2013 Jun 12;33(24):9998-10010.
2. Goodfellow VS, et al. J Med Chem. 2013 Oct 24;56(20):8032-48.
3. Zhang G, et al. Nanomedicine. 2016 Jan;12(1):109-22.
4. Polesskaya O, et al. Mol Immunol. 2014 Apr;58(2):214-22.
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