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M443

Chemical Structure : M443

CAS No.: 1820684-31-8

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M443 (ZAK inhibitor M443)

Catalog No.: PC-70175Not For Human Use, Lab Use Only.

M443 (M 443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    M443 (M 443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.
    M-443 effectively inhibits MRK downstream signals in primary medulloblastoma cells and prevents cell-cycle arrest induced by IR.
    M-443 also inhibits radiation-induced activation of both p38 and Chk2.
    M-443 achieves a synergistic increase in survival in an animal model of medulloblastoma.

    Physicochemical Properties

    M.Wt 589.623
    Formula C31H30F3N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((4-(1-acryloylpiperidin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

    References

    1. Markowitz D, et al. Mol Cancer Ther. 2016 Aug;15(8):1799-808.

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