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CLFB-1134

Chemical Structure : CLFB-1134

CAS No.: 1627729-62-7

CLFB-1134 (CLFB1134)

Catalog No.: PC-23625Not For Human Use, Lab Use Only.

CLFB-1134 is a potent, specific and brain-penetrant inhibitor of mixed lineage kinase-3 (MLK3) with IC50 of 42 nM.

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Biological Activity

CLFB-1134 is a potent, specific and brain-penetrant inhibitor of mixed lineage kinase-3 (MLK3) with IC50 of 42 nM.
CLFB-1134 decreases phosphorylation of JNK in the midbrain.
CLFB-1134 protects nigral dopamine neurons and striatal dopamine terminals in neurotoxin mouse model of Parkinson's disease.

Physicochemical Properties

M.Wt 432.50
Formula C23H20N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-amine

References

1. Kline EM, et al. Exp Neurol. 2019 Aug;318:157-164.

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