Chemical Structure : CLFB-1134
CAS No.: 1627729-62-7
Catalog No.: PC-23625Not For Human Use, Lab Use Only.
CLFB-1134 is a potent, specific and brain-penetrant inhibitor of mixed lineage kinase-3 (MLK3) with IC50 of 42 nM.
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CLFB-1134 is a potent, specific and brain-penetrant inhibitor of mixed lineage kinase-3 (MLK3) with IC50 of 42 nM.
CLFB-1134 decreases phosphorylation of JNK in the midbrain.
CLFB-1134 protects nigral dopamine neurons and striatal dopamine terminals in neurotoxin mouse model of Parkinson's disease.
M.Wt | 432.50 | |
Formula | C23H20N4O3S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(3,4-dimethoxyphenyl)-3-(7-methoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-amine |
1. Kline EM, et al. Exp Neurol. 2019 Aug;318:157-164.
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