Catalog No.: PC-24408Not For Human Use, Lab Use Only.
MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.
MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.
MBA-m1 is as effective as Nec1s in mouse cells, acts by disrupting the Hc/groove interaction.
MBA-m1 inhibits necroptosis in Mlkl−/− NIH-3T3 cells re-expressing mMLKL2, does not affect RIPK3:MLKL interaction.
MBA-m1 ameliorates disease in mouse models of MLKL-driven dermatitis and abdominal aortic aneurysm.
MBA-m1 harbored significantly lower counts of CD68+ macrophages and Ly6G+ myeloid cells compared with those treated with vehicle in mice.
