Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-Mixed Lineage Kinase (MLK)-MBA-m1
MBA-m1

Chemical Structure : MBA-m1

CAS No.: 305866-70-0

MBA-m1

Catalog No.: PC-24408Not For Human Use, Lab Use Only.

MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.
    MBA-m1 is as effective as Nec1s in mouse cells, acts by disrupting the Hc/groove interaction.
    MBA-m1 inhibits necroptosis in Mlkl−/− NIH-3T3 cells re-expressing mMLKL2, does not affect RIPK3:MLKL interaction.
    MBA-m1 ameliorates disease in mouse models of MLKL-driven dermatitis and abdominal aortic aneurysm.
    MBA-m1 harbored significantly lower counts of CD68+ macrophages and Ly6G+ myeloid cells compared with those treated with vehicle in mice.

    Physicochemical Properties

    M.Wt 440.93
    Formula C27H21ClN2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-6-methoxy-2-methylquinolin-4-amine

    References

    1. Ros U, et al. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: