CEP1347 (KT7515) | MLK inhibitor | ProbeChem Biochemicals

Chemical Structure : CEP1347

CAS No.: 156177-65-0

CEP1347 (KT-7515, KT7515, CEP-1347)

Catalog No.: PC-70174Not For Human Use, Lab Use Only.

CEP1347 (KT7515) is a potent and selective mixed lineage kinase (MLK) inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.

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Biological Activity

CEP1347 (KT7515) is a potent and selective mixed lineage kinase (MLK) inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.
CEP1347 has weak inhibitory activity for Trk A and MLCK.
CEP1347 promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade.
CEP1347 inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells.
CEP1347 elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases.

Physicochemical Properties

M.Wt	615.76
Formula	C33H33N3O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (5R,7R,8S)-2,11-bis((ethylthio)methyl)-7-hydroxy-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxylate

References

1. Kaneko M, et al. J Med Chem. 1997 Jun 6;40(12):1863-9.

2. Maroney AC, et al. J Neurosci. 1998 Jan 1;18(1):104-11.

3. Maroney AC, et al. J Biol Chem. 2001 Jul 6;276(27):25302-8.

4. Eggert D, et al. J Immunol. 2010 Jan 15;184(2):746-56.

CEP1347 (KT-7515, KT7515, CEP-1347)

Biological Activity

Physicochemical Properties

References

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