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Chemical Structure : LXY18
Catalog No.: PC-20713Not For Human Use, Lab Use Only.
LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies.
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LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies.
LXY18 potently inhibits 2C19 with an IC50 of 290 nM but has a negligible impact on the other CYP450s, indicating a low risk of drug-drug interaction.
LXY18 prevents cytokinesis by blocking AURKB relocalization in mitosis and exhibits broad-spectrum antimitotic activity in vitro.
LXY18 shows widespread tissue distribution including the blood-brain barrier penetrance and effective accumulation in tumor tissues.
LXY18 markedly suppresses tumor growth in vivo.
| M.Wt | 387.23 | |
| Formula | C18H15BrN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li J, et al. J Pharm Biomed Anal. 2023 Apr 24;232:115415.
2. J. Li, et al. BioRxiv, 2023 (2023), 10.1101/2023.01.29.526078
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