6K465 | Aurora A inhibitor | Probechem Biochemicals

You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Aurora Kinase-6K465

Chemical Structure : 6K465

6K465 (AURKA inhibitor 6K465)

Catalog No.: PC-22139Not For Human Use, Lab Use Only.

6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.
6K465 reduces levels of c-MYC and N-MYC oncoproteins more potently than alisertib.
6K465 dispalys potent antiproliferative effect an sensitivity against cell lung cancer (SCLC) and breast cancer (BC) cell lines with high protein levels of c-MYC and/or N-MYC.

Physicochemical Properties

M.Wt	542.05
Formula	C26H33ClFN9O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-Chloro-2-fluorophenyl)[4-[[4-(4-ethyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]amino]-1-piperidinyl]methanone

References

1. Chang CP, et al. Mol Cancer Ther. 2024 Apr 9. doi: 10.1158/1535-7163.MCT-23-0602.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

6K465 (AURKA inhibitor 6K465)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.