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Chemical Structure : MK-8745
CAS No.: 885325-71-3
Catalog No.: PC-22868Not For Human Use, Lab Use Only.
MK-8745 (MK8745) a potent, specific Aurora kinase A (Aurora A, AURKA) inhibitor with IC50 of 0.6 nM, induces apoptotic cell death in a p53-dependent manner.
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|---|---|---|---|
| 50 mg | $128 | In stock | |
| 100 mg | $218 | In stock | |
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MK-8745 (MK8745) a potent, specific Aurora kinase A (Aurora A, AURKA) inhibitor with IC50 of 0.6 nM, induces apoptotic cell death in a p53-dependent manner.
MK-8745 induces cell cycle arrest at the G2/M phase with accumulation of tetraploid nuclei followed by cell death in non-Hodgkin lymphoma (NHL) cell lines.
Exposure of p53 wild-type cells to MK8745 resulted in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression.
| M.Wt | 431.91 | |
| Formula | C20H19ClFN5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3-Chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]methanone |
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1. Chowdhury A, et al. Leuk Lymphoma. 2012 Mar;53(3):462-71.
2. Nair JS, et al. Cell Cycle. 2012 Feb 15;11(4):807-17.
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