Chemical Structure : CAM2602
CAS No.:
CAM2602
(CAM-2602)
Catalog No.: PC-22957Not For Human Use, Lab Use Only.
CAM2602 is a potent, selective small molecule inhibitor of Aurora A-TPX2 protein-protein interaction (PPI), binds to Aurora A and displaces TPX2 from Aurora A with a KD of 19 nM,
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CAM2602 is a potent, selective small molecule inhibitor of Aurora A-TPX2 protein-protein interaction (PPI), binds to Aurora A and displaces TPX2 from Aurora A with a KD of 19 nM,
CAM2602 is highly specific to Aurora A over Aurora B.
CAM2602 (20 uM) inhibits Aurora A phosphorylation in Jurkat cells, CAM2602 (200 mg/kg) decreases in the Aurora A P-Thr288 marker.
CAM2602 (100 or 150 mg/kg, daily oral) induces growth suppression in NSG mice bearing subcutaneous, solid tumor xenografts of Jurkat cells, synergizes with paclitaxel to suppress the outgrowth of pancreatic cancer cells.
Physicochemical Properties
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M.Wt
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484.96
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Formula
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C23H21ClN4O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(4-Chloro-3-(pyridin-2-yloxy)phenyl)-N-(N,N-dimethylsulfamoyl)-7-methyl-1H-indole-6-carboxamide
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References
1. Stockwell SR, et al. J Med Chem. 2024 Aug 27. doi: 10.1021/acs.jmedchem.4c01165.
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