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Chemical Structure : JAB-2485
Catalog No.: PC-22152Not For Human Use, Lab Use Only.
JAB-2485 is a potent, highly selective small-molecule Aurora kinase A (AURKA) inhibitor with IC50 of 0.33 nM, with >1500-fold selectivity over AURKB and AURKC.
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JAB-2485 is a potent, highly selective small-molecule Aurora kinase A (AURKA) inhibitor with IC50 of 0.33 nM, with >1500-fold selectivity over AURKB and AURKC.
JAB-2485 significantly decreases the level of AURKA phosphorylation in a dose-dependent manner.
JAB-2485 induces cell cycle arrest and apoptosis in NCI-H446 cells, with minimal myelosuppression.
JAB-2485 inhibits in vitro proliferation of small cell lung cancer (SCLC), triple-negative breast cancer (TNBC) and neuroblastoma cell lines ( NCI-H2171, IC50=46.1 nM; SH-SY5Y IC50=8.1 nM).
JAB-2485 (10 mpk, p.o. QD) significantly inhibited in vivo tumor growth on MDA-MB-231 xenografts.
| M.Wt | 503.98 | |
| Formula | C25H28ClF2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guiqun Yang, et al. Cancer Res (2023) 83 (7_Supplement): 1645.
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