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Reversine

Chemical Structure : Reversine

CAS No.: 656820-32-5

Reversine

Catalog No.: PC-21560Not For Human Use, Lab Use Only.

Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively.
Reversine promotes the dedifferentiation of committed cells into multipotent progenitor-type cells.
Reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia.

Physicochemical Properties

M.Wt 393.50
Formula C21H27N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N6-Cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine

References

1. D'Alise AM, et al. Mol Cancer Ther2008 May;7(5):1140-9.

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