Chemical Structure : Tinengotinib
Catalog No.: PC-73448Not For Human Use, Lab Use Only.
Tinengotinib (TT-00420) is a spectrum-selective multikinase inhibitor that targets cell proliferation, angiogenesis, and immunomodulatory pathways by inhibiting Aurora A/B and JAK involved in cytokine signalling, and RTKs involved in angiogenesis (FGFRs and VEGFRs).
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Tinengotinib (TT-00420) is a spectrum-selective multikinase inhibitor that targets cell proliferation, angiogenesis, and immunomodulatory pathways by inhibiting Aurora A/B and JAK involved in cytokine signalling, and RTKs involved in angiogenesis (FGFRs and VEGFRs).
TT-00420 has demonstrated anti-tumor activity in both in vitro and in vivo preclinical models of solid tumors, including triple-negative breast cancer (TNBC) and cholangiocarcinoma (CCA).
M.Wt | 394.863 | |
Formula | C20H19ClN6O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Sarina A. Piha-Paul, et al. Cancer Res (2020) 80 (16_Supplement): 3011.
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