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Tinengotinib

Chemical Structure : Tinengotinib

CAS No.: 2230490-29-4

Tinengotinib (TT-00420, TT00420)

Catalog No.: PC-73448Not For Human Use, Lab Use Only.

Tinengotinib (TT-00420) is a spectrum-selective multikinase inhibitor that targets cell proliferation, angiogenesis, and immunomodulatory pathways by inhibiting Aurora A/B and JAK involved in cytokine signalling, and RTKs involved in angiogenesis (FGFRs and VEGFRs).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Tinengotinib (TT-00420) is a spectrum-selective multikinase inhibitor that targets cell proliferation, angiogenesis, and immunomodulatory pathways by inhibiting Aurora A/B and JAK involved in cytokine signalling, and RTKs involved in angiogenesis (FGFRs and VEGFRs).
TT-00420 has demonstrated anti-tumor activity in both in vitro and in vivo preclinical models of solid tumors, including triple-negative breast cancer (TNBC) and cholangiocarcinoma (CCA).

Physicochemical Properties

M.Wt 394.863
Formula C20H19ClN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Sarina A. Piha-Paul, et al. Cancer Res (2020) 80 (16_Supplement): 3011.

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