| Cat. No. |
Product Name |
Information |
| PC-42734 |
Fexaramine
FXR agonist
|
Fexaramine is a potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064. |
| PC-45980 |
Chenodeoxycholic Acid
FXR agonist
|
Chenodeoxycholic Acid (CDDA) is a potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). |
| PC-45825 |
GW-4064
FXR agonist
|
GW-4064 (GW4064) is a potent and selective FXR agonist with EC50 of 15 nM in cell-free assay, >200-fold more potent than CDCA. |
| PC-42924 |
INT-747
FXR agonist
|
INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM). |
| PC-45904 |
WAY-362450
FXR agonist
|
A highly potent, selective, and orally active agonist of FXR with EC50 of 4 nM. |
| PC-23132 |
Dual FXR-LIFR modulator 3a
LIFR antagonist/FXR agonist
|
Dual FXR-LIFR modulator 3a is a first-in-class hybrid leukemia inhibitory factor receptor (LIFR) inhibitor and Farnesoid X receptor (FXR) agonist with IC50 of 2.0 uM and EC50 of 3.2 uM respectively, protects against the development of acute liver fibrosis and inflammation. |
| PC-22657 |
Agmatine sulfate
FXR agonist
|
Agmatine sulfate is a microbial metabolite derived from arginine by arginine decarboxylase, activates the farnesoid X receptor (FXR) pathway to subsequently inhibit glucagon-like peptide-1 (GLP-1) secretion by L cells. |
| PC-22169 |
F44-A13
FXR antagonist
|
F44-A13 is a highly selective farnesoid X receptor (FXR) antagonist with IC50 of 1.1 uM, with high selectivity over eleven other nuclear receptors. |
| PC-21879 |
ID166
FXR agonist
|
ID119031166 (ID166) is a novel potent, selective FXR agonist with EC50 of 3 nM and 5 nM in TR-FRET FXR co-activator assay and FXR reporter assay, respectively. |
| PC-20980 |
HPG1860
FXR agonist
|
HPG1860 is a potent, selective, nonbile acid full FXR agonist with EC50 of 5 nM and 18 nM in FR-FRET and luciferase assays, respectively. |
| PC-20979 |
MET409
FXR agonist
|
MET409 (MET-409) is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 16 nM (human FXR). |
| PC-20976 |
BMS-986318
FXR agonist
|
BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays. |
