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Chenodeoxycholic Acid

Chemical Structure : Chenodeoxycholic Acid

CAS No.: 474-25-9

Chenodeoxycholic Acid (CDCA)

Catalog No.: PC-45980Not For Human Use, Lab Use Only.

Chenodeoxycholic Acid (CDDA) is a potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR).

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Biological Activity

Chenodeoxycholic Acid (CDDA) is a potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR).
CDDA increases plasma concentrations of GLP-1, C-peptide, glucagon, peptide YY, neurotensin, total bile acids, and FGF19 significantly compared with placebo.
CDDA also activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis.

Physicochemical Properties

M.Wt 392.572
Formula C24H40O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 3.6 mg/mL

Chemical Name/SMILES

Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7α)-

References

1. Parks DJ, et al. Science. 1999 May 21;284(5418):1365-8.

2. Nielsen S, et al. Physiol Rep. 2017 Feb;5(3). pii: e13140.

3. Gong Z, et al. Oncotarget. 2016 Dec 20;7(51):83951-83963.

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