GSK2324 | FXR agonist | Probechem Biochemicals

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Chemical Structure : GSK2324

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GSK2324 (GSK 2324)

Catalog No.: PC-60080Not For Human Use, Lab Use Only.

GSK2324 (GSK 2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK2324 (GSK 2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.
GSK2324 lowers body weight gain and serum glucose in a DIO mouse model of diabetes.

Physicochemical Properties

M.Wt	533.405
Formula	C29H22Cl2N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)quinoline-2-carboxylic acid

References

1. Bass JY, et al. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13.

2. de Aguiar Vallim TQ, et al. Circ Res. 2013 Jun 7;112(12):1602-12.

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GSK2324 (GSK 2324)

Biological Activity

Physicochemical Properties

References

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