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Chemical Structure : INT-747
CAS No.: 459789-99-2
Catalog No.: PC-42924Not For Human Use, Lab Use Only.
INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $68 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | Get quote |
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INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM).
INT-747 possesses anticholeretic activity in rat model of cholestasis.
| M.Wt | 420.6252 | |
| Formula | C26H44O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Cholan-24-oic acid, 6-ethyl-3,7-dihydroxy-, (3α,5β,6α,7α)- |
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1. Pellicciari R, et al. J Med Chem. 2002 Aug 15;45(17):3569-72.
2. Fiorucci S, et al. J Pharmacol Exp Ther. 2005 May;313(2):604-12.
3. Rizzo G, et al. Mol Pharmacol. 2006 Oct;70(4):1164-73.
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