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INT-747

Chemical Structure : INT-747

CAS No.: 459789-99-2

INT-747 (Obeticholic acid;6-ECDCA;6-Ethylchenodeoxycholic acid;INT747)

Catalog No.: PC-42924Not For Human Use, Lab Use Only.

INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM).
INT-747 possesses anticholeretic activity in rat model of cholestasis.

Physicochemical Properties

M.Wt 420.6252
Formula C26H44O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

Cholan-24-oic acid, 6-ethyl-3,7-dihydroxy-, (3α,5β,6α,7α)-

References

1. Pellicciari R, et al. J Med Chem. 2002 Aug 15;45(17):3569-72.

2. Fiorucci S, et al. J Pharmacol Exp Ther. 2005 May;313(2):604-12.

3. Rizzo G, et al. Mol Pharmacol. 2006 Oct;70(4):1164-73.

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