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Dual FXR-LIFR modulator 3a

Chemical Structure : Dual FXR-LIFR modulator 3a

CAS No.: 2409154-23-8

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Dual FXR-LIFR modulator 3a

Catalog No.: PC-23132Not For Human Use, Lab Use Only.

Dual FXR-LIFR modulator 3a is a first-in-class hybrid leukemia inhibitory factor receptor (LIFR) inhibitor and Farnesoid X receptor (FXR) agonist with IC50 of 2.0 uM and EC50 of 3.2 uM respectively, protects against the development of acute liver fibrosis and inflammation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Dual FXR-LIFR modulator 3a is a first-in-class hybrid leukemia inhibitory factor receptor (LIFR) inhibitor and Farnesoid X receptor (FXR) agonist with IC50 of 2.0 uM and EC50 of 3.2 uM respectively, protects against the development of acute liver fibrosis and inflammation.

Physicochemical Properties

M.Wt 454.30
Formula C24H17Cl2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4'-((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)methoxy)-[1,1'-biphenyl]-3-carboxylic acid

References

1. Rapacciuolo P, et al. J Med Chem. 2024 Oct 9. doi: 10.1021/acs.jmedchem.4c01651.

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