Dual FXR-LIFR modulator 3a

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Chemical Structure : Dual FXR-LIFR modulator 3a

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Catalog No.: PC-23132Not For Human Use, Lab Use Only.

Dual FXR-LIFR modulator 3a is a first-in-class hybrid leukemia inhibitory factor receptor (LIFR) inhibitor and Farnesoid X receptor (FXR) agonist with IC50 of 2.0 uM and EC50 of 3.2 uM respectively, protects against the development of acute liver fibrosis and inflammation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	454.30
Formula	C24H17Cl2NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4'-((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)methoxy)-[1,1'-biphenyl]-3-carboxylic acid

References

1. Rapacciuolo P, et al. J Med Chem. 2024 Oct 9. doi: 10.1021/acs.jmedchem.4c01651.

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