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Chemical Structure : WAY-362450
CAS No.: 629664-81-9
Catalog No.: PC-45904Not For Human Use, Lab Use Only.
A highly potent, selective, and orally active agonist of FXR with EC50 of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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WAY-362450 (Turofexorate isopropyl, XL335) highly potent, selective, and orally active agonist of FXR with EC50 of 4 nM.
WAY-362450 shows no significant cross-reactivity with a panel of nuclear receptors, including LXR, PPAR, RAR, RXR, GR, etc.
WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis, and promotes cholesterol lowering in models of dyslipidemia.
| M.Wt | 438.4665 | |
| Formula | C25H24F2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15 mg/mL |
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| Chemical Name/SMILES |
Azepino[4,5-b]indole-5-carboxylic acid, 3-(3,4-difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethyl-, 1-methylethyl ester |
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1. Flatt B, et al. J Med Chem. 2009 Feb 26;52(4):904-7.
2. Zhang S, et al. J Hepatol. 2009 Aug;51(2):380-8.
3. Evans MJ, et al. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G543-52.
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