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Chemical Structure : HPG1860
Catalog No.: PC-20980Not For Human Use, Lab Use Only.
HPG1860 is a potent, selective, nonbile acid full FXR agonist with EC50 of 5 nM and 18 nM in FR-FRET and luciferase assays, respectively.
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HPG1860 is a potent, selective, nonbile acid full FXR agonist with EC50 of 5 nM and 18 nM in FR-FRET and luciferase assays, respectively.
HPG1860 shows extensive selectivity profiling across TGR5, and 13 relevant nuclear receptors in a cAMP biological assay with EC50s >30.0 μM.
HPG1860 (3 mg/kg, oral) shows clear in vivo efficacy of upregulating FXR target genes (SHP, BSEP, and FGF15) in liver and ileum in male C57/BL6J mice.
HPG1860 (30 mg/kg) shows potent antifibrosis and anti-NASH activities in HFD-CCl4-induced mouse model.
| M.Wt | 573.49 | |
| Formula | C27H26Cl2N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mo C, et al. J Med Chem. 2023 Jul 9. doi: 10.1021/acs.jmedchem.3c00456.
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