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Chemical Structure : Fexaramine
CAS No.: 574013-66-4
Catalog No.: PC-42734Not For Human Use, Lab Use Only.
Fexaramine is a potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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Fexaramine is a potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064.
Fexaramine shows no transcriptional activity against hRXRα, hPPARα/γ/δ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR.
Fexaramine strongly induces target genes SHP, PLTP BSEP, and MRP-2 in the HEPG2 liver cell system.
Fexaramine robustly induces FGF15, leading to alterations in BA composition.
| M.Wt | 496.6398 | |
| Formula | C32H36N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester |
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1. Downes M, et al. Mol Cell. 2003 Apr;11(4):1079-92.
2. Fang S, et al. Nat Med. 2015 Feb;21(2):159-65.
3. Cho SW, et al. J Bone Miner Res. 2013 Oct;28(10):2109-21.
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