Chemical Structure : Fexaramine-3
CAS No.:
2115706-15-3
Fexaramine-3
(Fex-3, Fex3)
Catalog No.: PC-26701Not For Human Use, Lab Use Only.
Fexaramine-3 (Fex-3, Fex3) is a potent, selective intestinal-restricted FXR agonist. significantly promotes the mRNA expression of BSEP and SHP and suppresses CYP7A1, all of which are the target genes of FXR.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Fexaramine-3 (Fex-3, Fex3) is a potent, selective intestinal-restricted FXR agonist. significantly promotes the mRNA expression of BSEP and SHP and suppresses CYP7A1, all of which are the target genes of FXR.
Fexaramine-3 (Fex-3) targeted on FXR in ileum and has better selectivity than fexaramine.
Fexaramine-3 (Fex-3) effectively alleviated cholestatic liver injury by activating the intestinal FXR-fibroblast growth factor 15 (FGF15) signaling pathway, subsequently suppressed hepatic cholesterol 7α-hydroxylase (CYP7A1) expression.
Fexaramine-3 (Fex-3) alleviates cholestatic liver injury via FGF15-CYP7A1 axis in mouse models.
Physicochemical Properties
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M.Wt
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569.71
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Formula
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C37H35N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)-6-(methylamino)-2-naphthamido)phenyl)acrylate
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References
1. Wang H, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3386-3390.
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