| Cat. No. |
Product Name |
Information |
| PC-45731 |
PRT4165
PRC1 inhibitor
|
PRT4165 (NSC 600157) is a potent inhibitor of PRC1-mediated H2A ubiquitylation, inhibits the E3 ubiquitin ligase activity of PRC1, but not RNF8. |
| PC-46931 |
Suramin sodium salt
Cullin-RING E3 ubiquitin ligase inhibitor
|
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34. |
| PC-42099 |
SZL P1-41
Skp2 inhibitor
|
SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro. |
| PC-24059 |
Lanatoside C
DENV inhibitor, FOXP3 inhibitor
|
Lanatoside C is a cardiac glycoside, has an IC50 of 0.19 μM for dengue virus (DENV) infection in HuH-7 cells, also potently inhibits FOXP3 activity by causing degradation of RUNX1, directly binds the E3 ligase STUB1 (ITC, Ka=13 uM). |
| PC-23887 |
Hakin-1
Hakai inhibitor
|
Hakin-1 (Hakai inhibitor-1) is a specific small molecule inhibitor of the E3 ubiquitin-ligase Hakai, reduces Hakai-mediated total ubiquitination and Hakai-mediated ubiquitination of E-cadherin. |
| PC-23661 |
Y043-4427
DTX2 inhibitor
|
Y043-4427 (mDTX2i, C22H24N4O2) is a potent small molecule inhibitor of Deltex E3 ubiquitin ligase 2 (DTX2) with IC50 of 30.83 uM in Hepa1-6 cells. |
| PC-22789 |
BC-1293
FBXO24 inhibitor
|
BC-1293 is a specific small molecule inhibitor of bacterial-induced ubiquitin E3 ligase subunit FBXO24, abrogates FBXO24-DARS2 binding, exhibits immunostimulatory properties. |
| PC-22418 |
PFI-E3H1
GID4 inhibitor
|
PFI-E3H1 is a potent, selective chemical handle of Gid4 subunit of the human E3 ligase CTLH degradation complex with IC50 of 2.5 uM in NanoBRET assay measuring the Gid4/MPGLWKS interaction. |
| PC-22417 |
PFI-7
GID4 inhibitor
|
PFI-7 is a potent, selective and cell-active chemical probe inhibitor for GID4, a substrate-binding receptor within the C-terminal to LisH (CTLH) E3 ligase complex. |
| PC-22133 |
LS-102
Synoviolin inhibitor
|
LS-102 is a selective small molecule inhibitor of E3 ubiquitin ligase Synoviolin (SYVN1), inhibits the autoubiquitination of synoviolin with IC50 of 35 uM. |
| PC-21791 |
MN714
SOCS2 inhibitor
|
MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2). |
| PC-21790 |
MN551
SOCS2 inhibitor
|
MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate. |
