| Cat. No. |
Product Name |
Information |
| PC-38778 |
WSB1 inhibitor 4
WSB1 inhibitor 4
|
WSB1 inhibitor 4 is a small molecule inhibitor and degarder of the ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1), displays migration inhibitory activity against WSB1-overexpressing cells. |
| PC-72549 |
CRL inhibitor 33-11
E3 CRL4 inhibitor
|
CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.6 and 1.7 uM, respecitvely. |
| PC-35676 |
cIAP1 E3 ligase inhibitor D19-14
|
cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro. |
| PC-35675 |
cIAP1 E3 ligase inhibitor D19
|
cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1. |
| PC-35074 |
inh-02
|
inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1. |
| PC-63041 |
TAME hydrochloride
|
TAME is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1). |
| PC-63040 |
proTAME
|
proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20). |
| PC-62451 |
VHL-IN-15
|
VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.. |
| PC-61735 |
SPOP-IN-6b
|
SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP). |
| PC-70324 |
Heclin
|
A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively. |
| PC-43435 |
TAME
|
A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1). |
