| Cat. No. |
Product Name |
Information |
| PC-25785 |
Cbl-b-IN-1
Cbl-b inhibitor
|
Cbl-b-IN-1 is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B) with IC50 of <100 nM, shows binding selectivity over C-CBL. |
| PC-25779 |
PF-G23
Cbl-b inhibitor
|
PF-G23 (CBL-B inhibitor G23) is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B), shows binding selectivity over C-CBL. |
| PC-25778 |
HST-1011
Cbl-b inhibitor
|
HST-1011 is a potent, selective, orally bioavailable allosteric small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B), robustly increases anti-tumor immunity in vitro and in vivo. |
| PC-25777 |
Cbl-b inhibitor 10
Cbl-b inhibitor
|
Cbl-b inhibitor 10 is a potent and orally bioavailable Casitas B-lineage lymphoma-b (CBLB, Cbl-b) inhibitor with biochemical IC50 of 9.1 nM, and EC50 of 180.6 nM in IL-2 secretion assays. |
| PC-25478 |
Skp2-Cks1 inhibitor E35
Skp2 inhibitor
|
Skp2-Cks1 inhibitor E35 is a potent small molecule inhibitor of S-phase kinase-associated protein 2 (Skp2), inhbits Skp2-Cks1 protein-protein interaction (PPI) with IC50 of 4.86 uM. |
| PC-25377 |
A5-MMC17
FBW7 modulator
|
A5-MMC17 is a specific, small molecule allosteric modulator of FBW7 E3 ligase with MST Kd of 45 uM, targets FBW7-pocket G, induces proteasome- and Cullin-RING-dependent c-MYC and c-JUN degradation in cells. |
| PC-25147 |
OICR-41103
DCAF1 ligand
|
OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein. |
| PC-24781 |
NEDD4 inhibitor 32
NEDD4 inhibitor
|
NEDD4 inhibitor 32 is a selective, covalent inhibitor of E3 ubiquitin ligases NEDD4 with IC50 of 0.12 uM, specifically target the non-catalytic cysteine C627, effectively inhibits NEDD4-mediated polyubiquitination. |
| PC-24708 |
Skp2 inhibitor E35
Skp2 inhibitor
|
Skp2 inhibitor E35 (HK-E35) is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 4.8 uM against Skp2-Cks1 binding. |
| PC-24707 |
Skp2 inhibitor 10h
Skp2 inhibitor
|
Skp2 inhibitor 10h is a potent S-phase kinase-associated protein 2 (Skp2) inhibitor with IC50 of 0.38 uM against Skp2-Cks1 binding. |
| PC-24706 |
ZK-14i
Skp2 inhibitor
|
ZK-14i (Skp2 inhibitor 14i) is a potent inhibitor of S-phase kinase-associated protein 2 (Skp2) with IC50 of 2.8 uM against the Skp2-Cks1 interaction. |
| PC-24524 |
GS143
E3 ligase β-TrCP inhibitor
|
GS143 is a specific small molecule inhibitor of E3 ligase β-TrCP, exhibits potent latency reversing agent (LRA) activity, also is a NF-kappaB signaling inhibitor, inhibits IκBα ubiquitylation (IC50=5.2 uM). |
