| Cat. No. |
Product Name |
Information |
| PC-70324 |
Heclin
HECT ligase inhibitor
|
Heclin is a small molecule inhibitor of HECT-type E3 ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively. |
| PC-61192 |
SCF-I2
SCFCdc4 inhibitor
|
SCF-I2 is an allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assays. |
| PC-60879 |
BC-1215
Fbxo3 inhibitor
|
BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL. |
| PC-60547 |
BC-1382
HECTD2 inhibitor
|
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM. |
| PC-60518 |
CC-220
E3 ubiquitin ligase modulator
|
Iberdomide (CC-220) is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM. |
| PC-45731 |
PRT4165
PRC1 inhibitor
|
PRT4165 (NSC 600157) is a potent inhibitor of PRC1-mediated H2A ubiquitylation, inhibits the E3 ubiquitin ligase activity of PRC1, but not RNF8. |
| PC-46931 |
Suramin sodium salt
Cullin-RING E3 ubiquitin ligase inhibitor
|
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34. |
| PC-42099 |
SZL P1-41
Skp2 inhibitor
|
SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro. |
| PC-26896 |
JWZ-8-103
NPC molecular glue degrader
|
JWZ-8-103 is a potent TRIM21-targeting molecular glue triggering nuclear pore complex (NPC) degradation, is 10-fold more potent than PRLX-93936 against parental PANC-1 (IC50=9.5 nM) and H661 cells overexpressing high levels of ectopic TRIM21 (IC50 <10 nM). |
| PC-26895 |
MAN-021
NPC molecular glue degrader
|
MAN-021 is a potent TRIM21-NUP98 molecular glue triggering nuclear pore complex (NPC) degradation, promotes TRIM21 to bind the nuclear pore protein NUP98, inhibits PANC-1 cell proliferation with EC50 of 1.9 nM. |
| PC-26824 |
DDB1 ligand-1
DDB1 ligand
|
DDB1 ligand-1 is a small molecule ligand of E3 ligase adapter protein DDB1 with TR-FRET IC50 of 26 nM, blocks the canonical DCAF/HBx peptide binding site of DDB1. |
| PC-26822 |
UBR2-IN-1
UBR2 inhibitor
|
UBR2-IN-1 is a selective, high-affinity peptidomimetic ligand / inhibitor of UBR box-containing ubiquitin E3 ligase UBR2. |
