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Chemical Structure : BC-1382
CAS No.: 1013753-99-5
Catalog No.: PC-60547Not For Human Use, Lab Use Only.
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $568 | In stock | |
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| 100 mg | Get quote |
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BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM.
BC-1382 drastically increases PIAS1 protein level with IC50 of 100 nM and improves PIAS1 protein stability, with no effect on PIAS3, PIAS4, and HECTD2 protein levels.
BC-1382 suppresses LPS-induced PIAS1 degradation and restores PIAS1 protein levels at 800 nM, and proinflammatory cytokines released by PBMCs。
BC-1382 attenuates LPS- and Pseudomonas aeruginosa-induced lung inflammation
| M.Wt | 459.561 | |
| Formula | C23H29N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-N-(1-((2-methoxybenzyl)amino)-1-oxopropan-2-yl)-1-(phenylsulfonyl)piperidine-4-carboxamide |
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1. Coon TA, et al. Sci Transl Med. 2015 Jul 8;7(295):295ra109.
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