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Chemical Structure : Suramin sodium salt
CAS No.: 129-46-4
Catalog No.: PC-46931Not For Human Use, Lab Use Only.
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.
Suramin also potently inhibits sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM).
Suramin induces accumulation of CRL substrates.
Suraminalso inhibits multiple viruses (ZIKVs, EV71).
| M.Wt | 1429.171 | |
| Formula | C51H34N6Na6O23S6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 200 mg/mL; DMSO: 5.6 mg/mL (Need warming) |
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| Chemical Name/SMILES |
1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, sodium salt (1:6) |
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1. Wu K, et al. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8.
2. Ren P, et al. Sci Rep. 2017 Feb 20;7:42902.
3. Albulescu IC, et al. Antiviral Res. 2017 Jul;143:230-236.
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