Heclin | HECT ligase inhibitor | Probechem Biochemicals

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Chemical Structure : Heclin

CAS No.: 890605-54-6

Heclin (HECT ligase inhibitor)

Catalog No.: PC-70324Not For Human Use, Lab Use Only.

Heclin is a small molecule inhibitor of HECT-type E3 ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Heclin is a small molecule inhibitor of HECT-type E3 ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.
Heclin does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys.
Heclin is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.

Physicochemical Properties

M.Wt	283.32
Formula	C17H17NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

References

1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41.

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Heclin (HECT ligase inhibitor)

Biological Activity

Physicochemical Properties

References

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