SPOP-IN-6b |CAS:2136270-20-5 Probechem Biochemicals

Chemical Structure : SPOP-IN-6b

SPOP-IN-6b

Catalog No.: PC-61735Not For Human Use, Lab Use Only.

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Biological Activity

SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP); suppresses oncogenic SPOP-signaling pathways, and kills human ccRCC cells that are dependent on oncogenic cytoplasmic SPOP.

Physicochemical Properties

M.Wt	500.603
Formula	C28H32N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide

References

1. Guo ZQ, et al. Cancer Cell. 2016 Sep 12;30(3):474-484.

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SPOP-IN-6b

Biological Activity

Physicochemical Properties

References

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