| Cat. No. |
Product Name |
Information |
| PC-72549 |
CRL inhibitor 33-11
E3 CRL4 inhibitor
|
CRL inhibitor 33-11 is a small moelcule cullin-RING E3 ubiquitin ligase 4 (E3 CRL4) inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely. |
| PC-72548 |
KH-4-43
E3 CRL4 inhibitor
|
KH-4-43 is a small moelcule E3 CRL4 inhibitor and exhibits antitumor potential, directly and selectively binds to the purified E3 ROC1-CUL4A CTD complex with Kd of 83 nM. |
| PC-72478 |
BC1618
Fbxo48 inhibitor
|
BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels. |
| PC-38305 |
PRC1 inhibitor RB-3
PRC1 inhibitor
|
PRC1 inhibitor RB-3 (RB-3) is a small molecule PRC1 inhibitor that directly bind to RING1B-BMI1 (KD=2.8 uM), the heterodimeric complex constituting the E3 ligase activity of PRC1. |
| PC-38239 |
MS.001
CHIP inhibitor
|
MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM). |
| PC-38107 |
Myomed-946
MuRF1 (TRIM63) inhibitor
|
MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression. |
| PC-38106 |
MyoMed-205
MuRF1 (TRIM63) inhibitor
|
MyoMed-205 is a small molecule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression. |
| PC-35959 |
HOIPIN-8
HOIP inhibitor
|
HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway. |
| PC-35958 |
HOIPIN-1
HOIP inhibitor
|
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.. |
| PC-35913 |
HS-152
SMURF1 inhibitor
|
HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively). |
| PC-35676 |
cIAP1 E3 ligase inhibitor D19-14
cIAP1 inhibitor
|
cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro. |
| PC-35675 |
cIAP1 E3 ligase inhibitor D19
cIAP1 inhibitor
|
cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1. |
