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Chemical Structure : Thiolutin
CAS No.: 87-11-6
Catalog No.: PC-49453Not For Human Use, Lab Use Only.
Thiolutin (Acetopyrrothin) is a small molecule inhibitor of the catalytic activity of E3 ubiquitin ligase HOIP, a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Thiolutin (Acetopyrrothin) is a small molecule inhibitor of the catalytic activity of E3 ubiquitin ligase HOIP, a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC).
Thiolutin inhibits JAB1/MPN/Mov34 (JAMM) domain-containing metalloprotease, blocks NLRP3 inflammasome activation by canonical, noncanonical, alternative, and transcription-independent pathways at nanomolar concentrations.
Thiolutin alleviated NLRP3-related diseases in mouse models of lipopolysaccharide-induced sepsis, monosodium urate-induced peritonitis, experimental autoimmune encephalomyelitis, CAPS, and methionine-choline-deficient diet-induced nonalcoholic fatty liver disease.
Thiolutin improved the survival of recipients in murine myeloid leukemia and suppressed propagation in the patient-derived xenograft model of myeloid leukemia.
| M.Wt | 228.29 | |
| Formula | C8H8N2O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide |
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1. Koji Jimbo, et al. Leukemia. 2022 Nov 9. doi: 10.1038/s41375-022-01750-7.
2. Guang-Ming Ren, et al. Sci Immunol. 2021 Apr 30;6(58):eabe2933.
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