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BC18813

Chemical Structure : BC18813

CAS No.: 2451937-25-8

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BC18813 (BC 18813)

Catalog No.: PC-49194Not For Human Use, Lab Use Only.

BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays.

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    Biological Activity

    BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays.
    BC18813 decreases TFEB ubiquitination and significantly reduces the measured interaction between DCAF7 and TFEB in nucleus of cells.
    BC18813 attenuates a wide range of viral infections including SARS-CoV-2 infection, prevents virally-triggered TFEB degradation and dose-dependently reduces OC43 coronavirus infection, reduces HCoV-OC43 NP expression with IC50 of 0.3 uM.

    Physicochemical Properties

    M.Wt 356.364
    Formula C20H13FN6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(7-fluoro-1H-indol-5-yl)-2-(pyridin-4-yl)pyrido[2,3-d]pyrimidin-4-amine

    References

    1. Yuan Liu, et al. Res Sq. 2021 Apr 23;rs.3.rs-419305.

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