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Chemical Structure : PELI1-EGFR inhibitor S62
Catalog No.: PC-20113Not For Human Use, Lab Use Only.
PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between PELI1 and EGFR, suppresses breast cancer metastasis.
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PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between Pellino-1 (PELI1) and EGFR, suppresses breast cancer metastasis.
PELI1-EGFR inhibitor S62 (5-10 uM) reduced both protein levels of PELI1 and EGFR in MDA-MB-231 cells, also decrease of the membrane EGFR.
PELI1-EGFR inhibitor S62 did not block the phosphorylation of EGFR upon EGF stimulation.
PELI1-EGFR inhibitor S62 reduced the tyrosine and threonine phosphorylation of PELI1 and K63-linked ubiquitination of EGFR.
PELI1-EGFR inhibitor S62 inhibited the metastasis of MDA-MB-231 cells MDA-MB-231 cells-derived tumor nodules in lung after caudal vein injection.
PELI1-EGFR inhibitor S62 is a disruptor of PELI1 and EGFR interaction but not binding to PELI1 or EGFR alone.
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins, EGFR is positively correlated with PELI1 expression in breast cancers.
| M.Wt | 412.59 | |
| Formula | C24H32N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qi J, et al. Oncogenesis. 2023 Feb 25;12(1):9.
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