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Chemical Structure : WSB1 inhibitor 4
Catalog No.: PC-38778Not For Human Use, Lab Use Only.
WSB1 inhibitor 4 is a small molecule inhibitor and degarder of the ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1), displays migration inhibitory activity against WSB1-overexpressing cells.
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WSB1 inhibitor 4 is a small molecule inhibitor and degarder of the ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1), displays migration inhibitory activity against WSB1-overexpressing cells.
WSB1 inhibitor 4 inhibited cell migration through elevating the levels of RhoGDI2 protein, inhibited WSB1-mediated metastasis of cancer cells.
WSB1 inhibitor 4 functions as a WSB1 degrader.
WSB1 inhibitor 4 showed promising pharmacokinetic profiles and an excellent effect in reducing the number of metastatic colonies in vivo.
| M.Wt | 334.419 | |
| Formula | C21H22N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Che J, et al. J Med Chem. 2021 Jun 24;64(12):8621-8643.
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