Chemical Structure : CRL inhibitor 33-11
Catalog No.: PC-72549Not For Human Use, Lab Use Only.
CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.6 and 1.7 uM, respecitvely.
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CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.
CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.
CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.
CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro.
M.Wt | 388.302 | |
Formula | C19H11F3N2O4 | |
Appearance | Solid | |
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1. Kenneth Wu, et al. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2007328118.
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