Catalog No.: PC-20292Not For Human Use, Lab Use Only.
OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP).
OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP).
OICR-8268 exhibits cellular target engagement with EC50 of 10 μM as measured by cellular thermal shift assay (CETSA).
OICR-8268 shows high affinity for binding to the DCAF1 WDR domain with ITC Kd of 278 nM.
OICR-8268 is a potent and in-cell active small molecule for the DCAF1 WDR domain.
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP), plays a critical physiological role in protein degradation, and is considered a drug target for various cancers.
