| Cat. No. |
Product Name |
Information |
| PC-35959 |
HOIPIN-8
HOIP inhibitor, LUBAC inhibitor
|
HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway. |
| PC-35958 |
HOIPIN-1
HOIP inhibitor
|
HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.. |
| PC-35913 |
HS-152
SMURF1 inhibitor
|
HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively). |
| PC-35676 |
cIAP1 E3 ligase inhibitor D19-14
cIAP1 inhibitor
|
cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro. |
| PC-35675 |
cIAP1 E3 ligase inhibitor D19
cIAP1 inhibitor
|
cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1. |
| PC-63515 |
BI8626
HUWE1 inhibitor
|
BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM). |
| PC-63514 |
BI8622
HUWE1 inhibitor
|
BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b). |
| PC-63321 |
BRD5529
CARD9-TRIM62 inhibitor
|
BRD5529 is a small-molecule inhibitor that disrupts the interaction of CARD9-E3 ubiquitin ligase TRIM62 with IC50 of 8.6 uM. |
| PC-62453 |
Skp2 Inhibitor C1
Skp2 inhibitor
|
Skp2 inhibitor C1 (CKS1i) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, induces p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases. |
| PC-62315 |
N-aryl benzimidazole
Rsp5/Nedd4 inhibitor
|
N-aryl benzimidazole (NAB) is a small molecule that strongly and selectively protects diverse cell types from α-syn toxicity, promotes endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4 in wild-type yeast cells. |
| PC-62313 |
Tasisulam
RBM39 degrader
|
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. |
| PC-62312 |
Tasisulam sodium
RBM39 degrader
|
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. |
